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Acute reserpine treatment alters the catecholamine, glucocorticoid and opioid response to walking exercise in sheep
K Pierzchała-Koziec1, J Niezgoda, D Wrońska-Fortuna
1Dept. of Animal Physiology, University of Agriculture, Cracow, Poland.
Abstract:
The aim of the study was to examine the effects of reserpine on the plasma levels of adrenaline, noradrenaline, cortisol and alpha-neoendorphin in sheep under control conditions and during walking exercise. One hour of walking (5 km/h) caused a significant increase in both catecholamines and cortisol between 10 and 30 min of stress, and transiently decreased the level of alpha-neoendorphin at the same time. Reserpine at the dose of 0.3 mg/kg i.v. given before stress significantly lowered the basal levels of all tested parameters. A combination of the reserpine and walking exercise significantly attenuated the stress-induced changes in the plasma level of measured hormones.
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