Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complete glottic closure during central apnea in lambs.

D Lemaire1, P Létourneau, D Dorion

  • 1Department of Pediatrics and Physiology, Faculty of Medicine, Université de Sherbrooke, Fleurimont, Quebec.

The Journal of Otolaryngology
|March 17, 1999
PubMed
Summary

Complete glottic closure occurs in most induced central apneas in lambs, confirmed by thyroarytenoid (TA) muscle EMG. This finding suggests a mechanism to maintain lung volume and improve gas exchange during apneas.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ovine model of congenital chest wall and spine deformity with alterations of respiratory mechanics: follow-up from birth to three months.

Studies in health technology and informatics·2021
Same author

Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study.

Brazilian journal of biology = Revista brasleira de biologia·2021
Same author

Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2011
Same author

[Laryngeal chemoreflexes and cardiorespiratory control in the neonatal period].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2008
Same author

Vascular endothelial growth factor (VEGF) levels as a tool to discriminate between malignant and nonmalignant ascites.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2004
Same author

Lessons from the year 2001 Mycosphaerella graminicola epidemic on winter wheat in Belgium.

Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen)·2003

Area of Science:

  • Respiratory Physiology
  • Neonatal Research
  • Sleep Studies

Background:

  • Understanding laryngeal function during apnea is crucial for respiratory control research.
  • The role of the thyroarytenoid (TA) muscle in glottic closure during central apneas requires further elucidation.

Purpose of the Study:

  • To document glottic closure during induced central apneas in lambs.
  • To confirm TA muscle electrical activity correlates with glottic closure.
  • To assess the physiological significance of glottic closure during apneas.

Main Methods:

  • Simultaneous recording of TA muscle EMG, subglottic pressure, and lung volume.
  • Direct endoscopic visualization of the glottis in lambs during induced central apneas.

Related Experiment Videos

Main Results:

  • Complete glottic closure was observed in 92% of induced central apneas.
  • TA muscle EMG activity consistently paralleled complete glottic closure (35/38 instances).
  • Positive subglottic pressure and maintained lung volume were noted during glottic closure.

Conclusions:

  • Complete glottic closure is a common event during induced central apneas in lambs.
  • TA muscle EMG is a reliable indicator of glottic closure during apneas.
  • Glottic closure may be a physiological mechanism to preserve lung volume and enhance gas exchange.