Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Sjögren's syndrome].

S Yoshida1

  • 1Department of Medicine, Fujita Health University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 17, 1999
PubMed
Summary
This summary is machine-generated.

Sjögren's syndrome (SS) is an autoimmune disease causing dry eyes and mouth. Research is exploring new diagnostic criteria, potential autoantigens like alpha-fodrin, and novel treatments beyond fluid replacement.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response of lipoprotein lipase to calorie intake in streptozotocin-induced diabetic rats.

Scandinavian journal of clinical and laboratory investigation·1992
Same author

Cerebral infarction in a patient with acute lymphoblastic leukemia after fresh-frozen plasma replacement during L-asparaginase therapy.

American journal of hematology·1992
Same author

DNA polymerase alpha, beta, and gamma activities in human lymphocytes stimulated by Tora-mame (Phaseolus vulgaris) lectin.

Biochemistry international·1992
Same author

Variability of origin of serratus anterior muscle in Japanese.

Kaibogaku zasshi. Journal of anatomy·1992
Same author

Effect of interferon (IFN) on refractory idiopathic thrombocytopenic purpura: administration of 6 million units of recombinant IFN alpha-2b.

Internal medicine (Tokyo, Japan)·1992
Same author

Mechanism of release of Ca2+ from intracellular stores in response to ionomycin in oocytes of the frog Xenopus laevis.

The Journal of physiology·1992
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Area of Science:

  • Rheumatology
  • Immunology
  • Ophthalmology

Background:

  • Sjögren's syndrome (SS) is a chronic autoimmune disorder.
  • It primarily affects exocrine glands, leading to keratoconjunctivitis sicca (dry eyes) and xerostomia (dry mouth).
  • Epidemiological data indicates a prevalence of approximately 0.06% in Japanese females.

Purpose of the Study:

  • To summarize the current understanding of Sjögren's syndrome.
  • To highlight diagnostic criteria and evolving diagnostic standards.
  • To review potential autoantigens and therapeutic strategies.

Main Methods:

  • Review of epidemiological data from Japan's Ministry of Health and Welfare (1994).
  • Identification of candidate autoantigens associated with SS autoimmunity.

Related Experiment Videos

  • Analysis of current treatment modalities for sicca complex and extraglandular involvement.

    • Main Results:

    • Sjögren's syndrome diagnosis relies on established criteria, with revisions anticipated.
    • Key autoantigens under investigation include alpha-fodrin and specific residues of Ro/SSA-52 kDa.
    • Standard treatment involves fluid replacement, with corticosteroids or immunosuppressants used for extraglandular manifestations.

    Conclusions:

    • Sjögren's syndrome management requires addressing both glandular and extraglandular symptoms.
    • Ongoing research focuses on refining diagnosis and developing novel therapeutic agents.
    • The field is actively investigating potential autoantigens to improve understanding and treatment.