Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Antiphospholipid syndrome].

K Takabayashi1

  • 1Second Department of Internal Medicine, Chiba University, School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 17, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Left ventricular systolic function after inhalation of beta-2 agonists in healthy athletes.

Scientific reports·2024
Same author

Effects of Arterial Stiffness on Cerebral WM Integrity in Older Adults: A Neurite Orientation Dispersion and Density Imaging and Magnetization Transfer Saturation Imaging Study.

AJNR. American journal of neuroradiology·2022
Same author

An Investigation of Water Diffusivity Changes along the Perivascular Space in Elderly Subjects with Hypertension.

AJNR. American journal of neuroradiology·2021
Same author

Discussion of "Attitude of physicians towards automatic alerting in computerized physician order entry systems".

Methods of information in medicine·2013
Same author

Data analysis and data mining: current issues in biomedical informatics.

Methods of information in medicine·2011
Same author

Evaluation of small-intestinal abnormalities in adult patients with Henoch-Schönlein purpura using video capsule.

Endoscopy·2011
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Antiphospholipid Syndrome (APS), or Hughes syndrome, involves antibodies targeting beta 2-GPI, not cardiolipin. This autoimmune disorder can cause thrombosis, atherosclerosis, and severe symptoms, including rare catastrophic cases.

Area of Science:

  • Immunology
  • Rheumatology
  • Vascular Medicine

Context:

  • Antiphospholipid Syndrome (APS), also known as Hughes syndrome, is an autoimmune disorder.
  • Recent research redefines the antigen for anticardiolipin antibodies (aCL).
  • Lupus Anticoagulant may be associated with anti-prothrombin antibodies.

Purpose:

  • To review current understanding of Antiphospholipid Syndrome (APS).
  • To highlight recent findings on aCL antigenicity and pathogenic antibodies.
  • To discuss the expanded spectrum of APS symptoms and rare variants.

Summary:

  • Anticardiolipin antibody (aCL) targets beta 2-glycoprotein I (beta 2-GPI) when bound to cardiolipin or oxidized, not cardiolipin itself.
  • Lupus Anticoagulant is now potentially identified as an anti-prothrombin antibody.

Related Experiment Videos

  • Clinical manifestations include livedo, Sneddon syndrome, pulmonary hypertension, skin ulcers, accelerated atherosclerosis, and thrombosis.
  • Both IgA aCL and IgG aCL are implicated in thrombosis.
  • Catastrophic APS is a rare but frequently fatal variant.

    • Impact:

    • Advances understanding of APS pathogenesis and antibody targets.
    • Expands the recognized clinical features and diagnostic considerations for APS.
    • Highlights the thrombotic and potentially atherosclerotic risks associated with APS.
    • Emphasizes the severity of rare catastrophic APS cases.