[Adult Still's disease].

Area of Science:

• Rheumatology
• Internal Medicine
• Immunology

Context:

• Adult onset Still's disease (AOSD) is a rare systemic autoinflammatory disorder.
• Characterized by fever, rash, and joint pain, its etiology remains unknown.
• While often benign, severe manifestations can occur, impacting multiple organ systems.

Purpose:

• To review the clinical presentation, diagnosis, and management of Adult onset Still's disease.
• To highlight severe complications and treatment strategies for refractory cases.

Summary:

• AOSD presents with characteristic fever, rash, and arthritis.
• Severe cases may include disseminated intravascular coagulation (DIC), hemophagocytosis, amyloidosis, and respiratory failure.
• Treatment involves NSAIDs, with corticosteroids (prednisolone) and DMARDs/immunosuppressants for severe or refractory disease.

Impact:

• Provides an overview of AOSD for clinicians.
• Emphasizes the importance of recognizing and managing severe complications.
• Informs treatment decisions for challenging AOSD cases.