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[Hematological manifestations].

S Kumakura1, H Ishikura, S Kobayashi

  • 1Third Divison of Internal Medicine, Shimane Medical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 17, 1999
PubMed
Summary

Connective tissue diseases (CTDs) often present with hematological issues like anemia and white blood cell abnormalities. CTDs can also increase risks for lymphoma, myelodysplastic syndrome, and acute myeloid leukemia, sometimes due to treatment or hemophagocytosis.

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Area of Science:

  • Hematology
  • Rheumatology
  • Pathology

Context:

  • Connective tissue diseases (CTDs) encompass a group of autoimmune disorders affecting various organs.
  • Hematological manifestations are common clinicopathological features of CTDs.
  • Understanding these hematological changes is crucial for diagnosis and management of CTDs.

Purpose:

  • To describe the spectrum of hematological manifestations in connective tissue diseases.
  • To discuss the association between CTDs and hematological malignancies.
  • To explore autoimmune-associated hemophagocytic syndrome (AAHS) in the context of CTDs.

Summary:

  • Hematological abnormalities, including anemia of chronic disorders (ACD), leukopenia, and thrombocytopenia, are frequent in CTDs.
  • Patients with CTDs face increased risks of developing hematological malignancies such as lymphoma, myelodysplastic syndrome (MDS), and acute myeloid leukemia (AML), particularly with certain therapies.
  • Autoimmune-associated hemophagocytic syndrome (AAHS), characterized by pancytopenia or bicytopenia due to hemophagocytosis, is another significant hematological complication directly related to CTDs.

Impact:

  • Highlights the importance of hematological monitoring in CTD patients.
  • Informs clinicians about potential hematological risks and complications.
  • Provides insights into the pathophysiology, diagnosis, and treatment of AAHS in CTDs.

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