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Related Experiment Videos

Artificial liver.

P Konstantin1, J Chang, V Otto

  • 1Fresenius AG, St. Wendel, Germany.

Artificial Organs
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

This study introduces an artificial liver support system to aid patients with fulminant hepatic failure. The novel system effectively removes both lipophilic and hydrophilic toxins from blood, offering a vital bridge to liver transplantation.

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Area of Science:

  • Biomedical Engineering
  • Hepatology
  • Artificial Organ Development

Background:

  • Fulminant hepatic failure (FHF) has a high mortality rate without liver transplantation.
  • A significant gap exists between the need for and availability of donor livers for transplantation.
  • Existing treatments lack comprehensive support for liver function during FHF and transplant waiting periods.

Purpose of the Study:

  • To develop and evaluate an artificial liver support system for FHF patients.
  • To assess the system's efficacy in removing both hydrophilic and lipophilic toxins.
  • To provide temporary liver support while awaiting transplantation.

Main Methods:

  • Development of an artificial liver system comprising a monitor, extracorporeal blood circuit, polysulfone dialyzer, and liquid membrane filter.

Related Experiment Videos

  • In vitro testing using porcine blood to evaluate toxin removal.
  • In vivo animal studies (pigs) to assess systemic effects.

    • Main Results:

    • The system demonstrated near-complete elimination of phenols, fatty acids, and mercaptans within 5 hours in vitro.
    • Efficient removal of hydrophilic toxins like ammonia was achieved.
    • Animal studies showed no significant adverse effects on blood gases, liver parameters, electrolytes, or blood cell counts.

    Conclusions:

    • The developed artificial liver system effectively removes a broad spectrum of toxins associated with hepatic failure.
    • The system shows promise as a temporary solution for patients with FHF, supporting them during the critical period before transplantation.
    • Further clinical evaluation is warranted to confirm safety and efficacy in human patients.