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Related Experiment Videos

The pressure-induced calcium deposition on crosslinked polyurethanes.

N Shunmugakumar1, M Jayabalan

  • 1Sree Chitra Tirunal Institute for Medical Sciences and Technology, Division for Technical Evaluation of Biomaterials, Trivandrum, India.

Artificial Organs
|June 1, 1992
PubMed
Summary

Pressure influences calcium deposition in polyurethanes. Increased soft segment content enhanced calcification in IPDI polymers but decreased it in SMDI polymers due to altered phase mixing and hydrophilicity.

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Area of Science:

  • Biomaterials science
  • Polymer chemistry
  • Materials science

Background:

  • Polyurethanes are widely used in biomedical applications.
  • Understanding factors influencing calcium deposition is crucial for material design.
  • Previous studies have explored calcification in various materials.

Purpose of the Study:

  • To investigate the effect of pressure on calcium deposition in crosslinked polyurethane systems.
  • To analyze the relationship between soft segment content and calcification in different polyurethane formulations.
  • To elucidate the role of phase mixing and hydrophilicity in pressure-induced calcification.

Main Methods:

  • Two polyurethane systems, IPDI-PTMG/PPG-TMP and SMDI-PTMG/PPG-TMP, were synthesized.
  • Materials were subjected to induced pressure to study calcification.

Related Experiment Videos

  • Calcium deposition was quantified and correlated with polymer composition and structure.

    • Main Results:

    • Calcium deposition in IPDI-based polyurethanes showed a linear increase with soft segment (PTMG) content.
    • In SMDI-based polyurethanes, increased soft segment content led to decreased calcium deposition.
    • Reduced phase mixing and hydrophilicity in SMDI polymers with higher soft segment content correlated with lower calcification.

    Conclusions:

    • Pressure significantly influences calcium deposition in crosslinked polyurethanes.
    • The effect of soft segment content on calcification is dependent on the polyurethane type (IPDI vs. SMDI).
    • Phase mixing and hydrophilicity are key factors mediating the observed calcification trends under pressure.