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Updated: Aug 12, 2026

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
13:36

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

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CpG motifs as immune adjuvants

D M Klinman1, K M Barnhart, J Conover

  • 1Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Klinman@A1.CBER.FDA.GOV

Vaccine
|March 17, 1999
PubMed
Summary

Synthetic DNA sequences containing specific CpG motifs act as powerful immune system boosters. These CpG oligodeoxynucleotides significantly enhance antibody and IFN-gamma production when linked to immunogens.

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