Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genomic imprinting: implications for human disease.

J G Falls1, D J Pulford, A A Wylie

  • 1Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina27710, USA.

The American Journal of Pathology
|March 18, 1999
PubMed
Summary

Genomic imprinting is an epigenetic process causing parent-of-origin specific gene expression, deviating from Mendelian genetics. Dysregulation of imprinted genes contributes to developmental issues and human diseases like cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outbreak of post-parturient infectious pustular vulvovaginitis in a New Zealand dairy herd.

New Zealand veterinary journal·2025
Same author

Prevalence studies for Theileria orientalis conducted during the early stages of the 2012 New Zealand epidemic of Theileria associated bovine anaemia.

Veterinary parasitology, regional studies and reports·2019
Same author

The effect of month, farm type and latitude on the level of anaemia associated with Theileria orientalis Ikeda type infection in New Zealand cattle naturally infected at pasture.

Research in veterinary science·2018
Same author

Clinical haematology and biochemistry profiles of cattle naturally infected with Theileria orientalis Ikeda type in New Zealand.

New Zealand veterinary journal·2017
Same author

Monitoring Theileria orientalis (Ikeda)-associated bovine anaemia in affected cattle over time.

Veterinary parasitology·2017
Same author

Using a rule-based envelope model to predict the expansion of habitat suitability within New Zealand for the tick Haemaphysalis longicornis, with future projections based on two climate change scenarios.

Veterinary parasitology·2017

Area of Science:

  • Epigenetics
  • Genetics
  • Developmental Biology

Background:

  • Genomic imprinting is an epigenetic phenomenon leading to monoallelic gene expression based on parental origin.
  • This process challenges Mendelian genetics principles.
  • Imprinted genes play crucial roles in embryonic development and adult behavior.

Purpose of the Study:

  • To review the fundamental mechanisms of genomic imprinting.
  • To explore the involvement of imprinted genes in various human diseases.
  • To highlight the significance of genomic imprinting in health and disease.

Main Methods:

  • Literature review of genomic imprinting.
  • Analysis of the role of imprinted genes in development.
  • Examination of imprinted gene dysregulation in human pathologies.

Related Experiment Videos

Main Results:

  • Genomic imprinting results in parent-specific gene silencing or activation.
  • Aberrant genomic imprinting is linked to developmental abnormalities.
  • Imprinted gene dysfunction is implicated in diseases including cancer.

Conclusions:

  • Genomic imprinting is a critical epigenetic mechanism with profound biological implications.
  • Understanding genomic imprinting is vital for diagnosing and potentially treating genetic disorders.
  • Further research into imprinted genes may offer therapeutic targets for imprinting-related diseases.