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Related Experiment Videos

Evidence for an additional cattle DQA locus, BoLA-DQA5.

A Gelhaus1, B Förster, C Wippern

  • 1Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine (BNI), Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany. gelhaus@bni.uni-hamburg.de

Immunogenetics
|March 18, 1999
PubMed
Summary

Researchers identified a new cattle gene, BoLA-DQA5, crucial for major histocompatibility complex class II. This finding enhances our understanding of cattle immune genetics and breed diversity.

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THE SPECIFICITY OF ANTI-HLA CLASS II MONOCLONAL ANTIBODIES IN CATTLE.

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics·2017

Area of Science:

  • Immunogenetics
  • Comparative genomics
  • Cattle genetics

Background:

  • The Major Histocompatibility Complex (MHC) class II genes are vital for immune responses in cattle.
  • Understanding genetic polymorphism within these genes is key to livestock breeding and disease resistance.

Purpose of the Study:

  • To identify and characterize novel alleles within the cattle MHC class II DQA locus.
  • To investigate the evolutionary history and distribution of newly identified alleles across cattle breeds.

Main Methods:

  • Genetic sequencing and analysis of cattle DNA.
  • RNA analysis to confirm gene transcription.
  • Southern blot and phylogenetic analyses for evolutionary insights.

Main Results:

Related Experiment Videos

  • Identification of a novel allele, BNI13, encoding a typical MHC class II alpha chain.
  • Designation of the new locus as BoLA-DQA5.
  • Phylogenetic analysis indicates BoLA-DQA5 separated after BoLA-DQA1/DQA2 divergence but before sheep and cattle DQA1 divergence.
  • BoLA-DQA5 is present in various cattle breeds but restricted to specific haplotypes.

Conclusions:

  • BoLA-DQA5 represents a distinct and evolutionarily significant locus within the cattle MHC class II region.
  • The distribution pattern of BoLA-DQA5 suggests specific evolutionary pressures and haplotype associations.
  • This discovery contributes to a deeper understanding of cattle immunogenetics and population diversity.