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Related Experiment Videos

Critical care apheresis: hepatic failure.

C E Wiles1

  • 1University of Maryland, Baltimore, USA.

Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis
|March 18, 1999
PubMed
Summary
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Hepatic failure is common in critical care, often managed medically. However, artificial organ support, including promising hybrid bioartificial liver devices, shows success in advanced liver failure cases, particularly as a bridge to transplant.

Area of Science:

  • Critical care medicine
  • Hepatology
  • Biomedical engineering

Background:

  • Hepatic failure is a frequent complication in intensive care units (ICUs).
  • While medical management and metabolic support are primary treatments, the efficacy of extracorporeal organ support for hepatic failure is less established than for renal or pulmonary failure.
  • Advanced liver failure presents significant therapeutic challenges.

Purpose of the Study:

  • To review the current role and potential of extracorporeal organ support in managing hepatic failure.
  • To highlight the advancements and promise of artificial liver support systems, particularly hybrid bioartificial liver substitutes.

Main Methods:

  • Literature review and synthesis of existing research on hepatic failure management in critical care.

Related Experiment Videos

  • Analysis of the application and outcomes of artificial organ support in advanced liver disease.
  • Evaluation of the potential of bioartificial liver devices.

    • Main Results:

    • Most hepatic dysfunction in the ICU is managed effectively through medical and metabolic interventions.
    • Extracorporeal organ support for hepatic failure is not as well-defined as for other organ failures.
    • Artificial organ support has demonstrated success in treating advanced liver failure.

    Conclusions:

    • Hybrid bioartificial liver substitutes represent a promising therapeutic option.
    • These advanced devices show particular potential as a bridge to liver transplantation for patients with end-stage liver disease.