Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Invasive group A streptococcal infections in children.

H D Davies1, B Schwartz

  • 1University of Calgary, Alberta, Canada.

Advances in Pediatric Infectious Diseases
|March 18, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A phase III randomized trial of BAY 12-9566 (tanomastat) as maintenance therapy in patients with advanced ovarian cancer responsive to primary surgery and paclitaxel/platinum containing chemotherapy: a National Cancer Institute of Canada Clinical Trials Group Study.

Gynecologic oncology·2006
Same author

Pooled safety analysis of BAY 43-9006 (sorafenib) monotherapy in patients with advanced solid tumours: Is rash associated with treatment outcome?

European journal of cancer (Oxford, England : 1990)·2006
Same author

How often should a port-A-cath be flushed?

Cancer investigation·2005
Same author

An NCIC-CTG phase I dose escalation pharmacokinetic study of the matrix metalloproteinase inhibitor BAY 12-9566 in combination with doxorubicin.

Investigational new drugs·2005
Same author

HTS magnetometers for fetal magnetocardiography.

Neurology & clinical neurophysiology : NCN·2005
Same author

Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors.

Annals of oncology : official journal of the European Society for Medical Oncology·2005
Same journal

Animals, humans, and antibiotics: implications of the veterinary use of antibiotics on human health.

Advances in pediatric infectious diseases·1999
Same journal

Bacterial diarrheal pathogens.

Advances in pediatric infectious diseases·1999
Same journal

Infections and immunizations of children with sickle cell disease.

Advances in pediatric infectious diseases·1999
Same journal

Travel medicine and health issues for families traveling with children.

Advances in pediatric infectious diseases·1999
Same journal

Infectious diseases in internationally adopted children: findings in children from China, Russia, and eastern Europe.

Advances in pediatric infectious diseases·1999
Same journal

Hepatitis C virus infection.

Advances in pediatric infectious diseases·1999
See all related articles

Invasive group A streptococcal infections are rising in children and adults. Early diagnosis and treatment, including antibiotics and supportive care, are crucial for improving outcomes and preventing spread.

Area of Science:

  • Infectious Diseases
  • Pediatrics
  • Microbiology

Background:

  • Invasive group A streptococcal infections and streptococcal toxic shock syndrome (STSS) are increasing causes of severe illness and death in both children and adults.
  • In pediatric cases, respiratory infections are frequent, alongside skin and soft tissue infections, often linked to varicella (chickenpox).

Purpose of the Study:

  • To highlight the importance of early diagnosis for invasive group A streptococcal infections.
  • To outline current treatment strategies and potential interventions for improving patient outcomes.
  • To identify areas for future research, including pathogeneses and risk factors.

Main Methods:

  • Review of clinical presentations and diagnostic challenges associated with invasive group A streptococcal infections.

Related Experiment Videos

  • Analysis of therapeutic approaches, including antimicrobial therapy, intravenous immunoglobulin (IVIG), and surgical interventions.
  • Consideration of chemoprophylaxis strategies for close contacts in high-risk scenarios.

    • Main Results:

    • Prompt recognition of symptoms and high clinical suspicion are vital for early diagnosis.
    • Combination therapy (clindamycin, IVIG for STSS, surgery for necrotizing fasciitis) shows promise in improving outcomes.
    • Chemoprophylaxis may be beneficial for household contacts of severely affected patients.

    Conclusions:

    • Effective management of invasive group A streptococcal infections requires a multi-faceted approach including timely diagnosis and appropriate treatment.
    • Ongoing research is needed to elucidate the links between infections, varicella, NSAID use, and the pathogenesis of severe manifestations like STSS and necrotizing fasciitis.
    • Further studies will clarify the risk of secondary transmission among close contacts.