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Related Experiment Videos

Nutrition in inflammatory bowel disease.

S H Murch1, J A Walker-Smith

  • 1University Department of Paediatric Gastroenterology, Royal Free Hospital, London, UK.

Bailliere'S Clinical Gastroenterology
|March 18, 1999
PubMed
Summary

Active intestinal inflammation disrupts nutrition, causing weight loss and growth issues. Nutritional interventions, like enteral nutrition and specific fatty acids, show promise in reducing inflammation and promoting healing in inflammatory bowel diseases.

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Area of Science:

  • Gastroenterology and Nutrition Science

Background:

  • Active intestinal inflammation significantly disrupts nutritional status.
  • This leads to reduced appetite, weight loss, and impaired somatic function, affecting growth and development in children.
  • Key inflammatory mediators like tumor necrosis factor-alpha and interleukins are implicated in this derangement.

Purpose of the Study:

  • To explore the impact of intestinal inflammation on nutrition.
  • To investigate the potential of nutritional interventions in managing inflammatory bowel diseases (IBD).
  • To highlight emerging therapeutic targets for nutritional treatment in IBD.

Main Methods:

  • Review of existing evidence on nutrition and inflammation in IBD.
  • Analysis of the role of specific cytokines and molecular mediators.

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  • Examination of the effects of enteral nutrition and specific nutrients.

    • Main Results:

    • Enteral nutrition alone can normalize pro-inflammatory cytokines and promote mucosal healing.
    • Specific components like n-3 polyunsaturated fatty acids may exert anti-inflammatory effects.
    • New molecular mediators of appetite and body composition offer potential for targeted therapies.

    Conclusions:

    • Nutritional programs can reduce mucosal inflammatory responses in IBD.
    • Enteral nutrition and specific nutrients show therapeutic potential.
    • Understanding molecular mediators like leptin and myostatin may enhance IBD nutritional management.