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Molybdenum toxicity: interactions between copper, molybdenum and sulphate
Agents and Actions
|November 1, 1976
Summary
Molybdenum toxicity can cause poor growth and anemia by interfering with copper metabolism. Sulphate and sulphur compounds significantly influence these interactions and toxicity levels.
Area of Science:
- Veterinary Medicine
- Toxicology
- Nutritional Biochemistry
Background:
- Molybdenum is an essential trace element, but excess intake can lead to toxicity.
- Interactions between molybdenum, copper, and sulphate are complex and impact animal health.
- Molybdenum toxicity manifests in various clinical signs across different species.
Purpose of the Study:
- To review the multifaceted interactions between molybdenum, copper, and sulphate.
- To elucidate the mechanisms underlying molybdenum toxicity.
- To explore the potential human health implications of molybdenum-sulphate-copper interactions.
Main Methods:
- Literature review of studies on molybdenum toxicity and its interactions.
- Analysis of effects on animal growth, blood parameters, and tissue composition.
- Examination of biochemical pathways involving copper, molybdenum, and sulphur metabolism.
Main Results:
- Molybdenum toxicity causes poor growth, anemia, anorexia, diarrhea, and deformities in various animal models.
- Sulphate and sulphur compounds modulate molybdenum toxicity and copper metabolism.
- Molybdenum affects copper distribution in plasma and its uptake/excretion, potentially via copper(II) molybdate formation.
- Interactions occur in ruminal microbial sulphide production and intestinal sulphate transport.
Conclusions:
- Molybdenum toxicity is significantly influenced by sulphate and sulphur availability.
- Understanding these interactions is crucial for managing animal health and preventing toxicity.
- Further research is warranted to explore molybdenum's role in human diseases like gout and multiple sclerosis.