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Altered copper and zinc metabolism in primary hyperparathyroidism
The American Journal of the Medical Sciences
|September 1, 1976
Summary
Urinary copper and zinc levels are elevated in primary hyperparathyroidism. Monitoring these minerals post-surgery may aid in diagnosing and treating the condition.
Area of Science:
- Endocrinology
- Mineral Metabolism
Background:
- Primary hyperparathyroidism is associated with altered mineral homeostasis.
- Urinary excretion of trace elements in this condition is not well understood.
Purpose of the Study:
- To investigate 24-hour urinary excretion and serum concentrations of copper and zinc in patients with primary hyperparathyroidism.
- To assess changes in these minerals following surgical treatment.
Main Methods:
- Measurement of 24-hour urinary copper and zinc excretion.
- Measurement of total serum copper and zinc concentrations.
- Analysis of mineral levels before and after parathyroidectomy.
Main Results:
- Elevated mean 24-hour urinary copper and zinc excretion in untreated primary hyperparathyroidism.
- Transient increase in urinary copper and zinc post-surgery.
- Urinary copper and zinc decreased in most patients after successful surgery, but remained elevated in one with persistent hypercalcemia.
Conclusions:
- Urinary copper and zinc excretion patterns may serve as diagnostic and therapeutic indicators for primary hyperparathyroidism.
- Persistent hypercalcemia can influence urinary mineral excretion post-surgery.