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CD30 in normal and neoplastic cells
1Department of Pathology and Kaplan Comprehensive Cancer Center, New York University Medical Center, New York, New York 10016, USA.
Insights
CD30, a molecule identified in 1982, plays a key role in diagnosing Hodgkin's Disease and Anaplastic Large Cell Lymphoma. Its function in lymphoid development and differentiation is increasingly understood.
Area of Science:
- Immunology
- Oncology
- Molecular Biology
Background:
- CD30 (Ki-1) molecule identified in 1982.
- Expressed by Reed-Sternberg cells in Hodgkin's Disease (HD).
- Crucial for differential diagnosis of HD and identifying Anaplastic Large Cell Lymphoma (ALCL).
Purpose of the Study:
- Provide an overview of CD30 research.
- Discuss the role of CD30 in normal lymphoid cells.
- Discuss the role of CD30 in neoplastic lymphoid cells.
Main Methods:
- Cloning of human and murine CD30.
- Utilizing genetically manipulated animal models.
Main Results:
- Expanded knowledge on CD30's physiological role.
- Characterization of CD30's function in lymphoid development and differentiation.
Conclusions:
- CD30 is vital in diagnosing lymphoid malignancies.
- CD30 influences normal lymphoid cell development.
- CD30 is implicated in neoplastic lymphoid cell behavior.
Abstract:
In 1982 Stein and coworkers identified a new molecule, CD30 (Ki-1), which is expressed by Reed-Sternberg (RS) cells of Hodgkin's Disease (HD) (1). Although CD30 is not a specific RS cell marker, its characterization has assumed an important role not only in the differential diagnosis of HD, but also in the identification of a morphologically and clinically distinct type of large cell lymphoma, now designated as anaplastic large cell lymphoma (ALCL) (2). The cloning of human and murine CD30 and the utilization of genetically manipulated animal models have rapidly expanded our knowledge on its physiological role in lymphoid development and differentiation. The goal of this review is to present an overview of this rapidly evolving field and discuss the role of CD30 in normal and neoplastic lymphoid cells.