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[EGF-dependent association of 20S-proteasome and alpha-RNP particles with the epidermal growth factor receptor in
I M Konstantinova1, R Wetzker, E B Burova
1Institute of Cytology, Russian Academy of Sciences, St. Petersburg.
Tsitologiia
|March 19, 1999
Abstract:
Here we demonstrate that the epidermal growth factor (EGF) induces association of prosomes (20S-proteasomes) with its receptor in A-431 cells. Additionally, ligand-dependent association of ribonucleoprotein particles (alpha-RNP), containing small ALU-like RNA, with the EGF receptor was demonstrated. A suggestion has been put forward on the involvement of prosomes and alpha-RNP in the EGF signal transmission to different stages of gene expression.