In vivo visualization of serotonin transporters in the human brain during fluoxetine treatment
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J Tauscher1, W Pirker, M de Zwaan
1Department of General Psychiatry, University Hospital of Vienna, Austria. johannes.tauscher@akh-wien.ac.at
Abstract:
Beta-CIT can be used as a tracer for SPECT to visualize serotonin transporters in the human brain. We present a case of bulimia nervosa and major depressive disorder, who had been treated with up to 60 mg/d fluoxetine for several weeks. Four hours after injection of the tracer more than 40% of serotonin transporters were blocked. To our knowledge, this is the first direct documentation of the pharmacodynamic action of fluoxetine in the human brain in vivo.
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