Related Experiment Videos
HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native
F K Tan1, D N Stivers, F C Arnett
1Department of Internal Medicine, The University of Texas-Houston Medical School, 77030, USA. tan@heart.med.uth.tmc.edu
Abstract:
Choctaw Native Americans in southeastern Oklahoma have the highest prevalence of scleroderma or systemic sclerosis yet found (469/100,000). An Amerindian HLA DR2 haplotype (DRB1*1602) was significantly associated with scleroderma in this population in a previous study. It is not known, however, if other disease genes are linked to this HLA haplotype. The regions flanking the HLA loci were studied with polymorphic microsatellite markers. An extended HLA DR2 (DRB1*1602, DQA1*0501, DQB1*0301, DPB1*1301) haplotype that includes the class I and III regions was identified which was significantly associated with scleroderma in the Oklahoma Choctaw. No other significant associations with microsatellite marker alleles immediately flanking the HLA region were found.