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[Microdetermination to creatinine in biological fluids by kinetic methods. Comparison with continuous flow methods].

D Grafmeyer, R Cohen, A Badinand

    Annales De Biologie Clinique
    |January 1, 1976
    PubMed
    Summary

    This study compares two Jaffe reaction-based micromethods for creatinine determination in biological fluids. Both methods showed good correlation with established continuous flow techniques, indicating their reliability for clinical use.

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    Area of Science:

    • Clinical Chemistry
    • Biochemical Analysis

    Background:

    • Accurate creatinine measurement is crucial for assessing kidney function.
    • Existing methods for creatinine determination vary in speed and complexity.

    Purpose of the Study:

    • To evaluate and compare the performance of two Jaffe reaction-based micromethods for creatinine determination.
    • To assess the clinical applicability of these micromethods by correlating their results with established techniques.

    Main Methods:

    • Utilized the Jaffe kinetic reaction for creatinine measurement.
    • Adapted one method to the LKB 8 600 rate reaction analyzer.
    • Employed the Centrifichem, a rapid centrifugal analysis system, for the second method.
    • Correlated results with continuous flow techniques incorporating dialysis.

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    Main Results:

    • Both micromethods demonstrated comparable performance in creatinine determination.
    • Results from both analyzers showed strong correlation with continuous flow methods.
    • The study validates the reliability of these micromethods for biological fluid analysis.

    Conclusions:

    • The evaluated Jaffe-based micromethods are suitable for routine creatinine determination.
    • These methods offer reliable and potentially faster alternatives to existing techniques.
    • The findings support the use of LKB 8 600 and Centrifichem for clinical creatinine analysis.