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Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the human nuclear factor
1Department of Molecular Biology, Nippon Medical School, Kawasaki, Japan.
Journal of Human Genetics
|March 20, 1999
Abstract:
The transcriptional factor nuclear factor kappa-beta (NFKB) consists of a multicomponent protein complex that plays a major role in the regulation of many viral and cellular genes. The NFKB complex has two alternative DNA binding subunits. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the NFKB subunit 1 (NFKB1) gene located at 4q23-24. High heterozygosity (0.813) makes this polymorphism a useful marker in the genetic study of disorders affecting the immune response and cell differentiation.