[Selective inhibition of cyclooxygense (COX-2)]

The author gives a brood outline of the circumstances of the inhibition of cyclooxygenase (COX) giving special emphasis to the different role of the two isoforms COX-1 and COX-2. More selective COX-2 inhibition can be have required practical effect in reducing of inflammation with less side effects. To set a correct determination of COX-2/COX-1 quotiens is difficult because of numerous methodical problems. We have to rely on the clinical experiences gained through long usage of some drugs.