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Ageing and growth hormone status.

A A Toogood¹, S M Shalet

¹Department of Endocrinology, Christie Hospital NHS Trust, Withington, Manchester, UK.

Bailliere'S Clinical Endocrinology and Metabolism

|March 20, 1999

Summary

Organic growth hormone (GH) deficiency in adults mimics aging, causing adverse changes. GH therapy may help elderly individuals with GH deficiency, potentially reversing age-related decline.

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Area of Science:

Endocrinology
Gerontology
Metabolic Research

Background:

Adult growth hormone (GH) deficiency presents adverse changes akin to aging.
GH secretion naturally declines with age, prompting investigation into its role in elderly individuals.
Hypothalamic-pituitary axis disease can significantly reduce GH secretion in the elderly.

Purpose of the Study:

To discuss the effects of organic GH deficiency in elderly subjects.
To explore the potential benefits of GH replacement therapy in the elderly.
To examine GH therapy's capacity to counteract age-related detrimental effects.

Main Methods:

Review of existing literature on GH deficiency in adults and the elderly.
Analysis of the impact of hypothalamic-pituitary disease on GH secretion.
Examination of body composition, IGF-1 levels, and bone turnover markers.

Main Results:

Organic GH deficiency in the elderly leads to reduced GH secretion (up to 90%) and lower IGF-1 levels.
Abnormal body composition and bone turnover are observed, though bone mineral density remains unaffected.
These changes are distinct from, yet less severe than, those in younger adults with organic GH deficiency.

Conclusions:

Organic GH deficiency in the elderly causes specific physiological changes.
GH replacement therapy holds potential for mitigating these changes and possibly some effects of aging.
Further research is warranted to fully understand GH therapy's role in geriatric endocrinology.

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