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Growth hormone and ovarian function.

S Franks1

  • 1Imperial College School of Medicine, St Mary's Hospital, London, UK.

Bailliere'S Clinical Endocrinology and Metabolism
|March 20, 1999
PubMed
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Growth hormone (GH) plays a role in adult ovarian function, augmenting granulosa cell proliferation and steroidogenesis. While beneficial in hypogonadotrophic hypogonadism, GH offers no significant advantage for PCOS or IVF.

Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Cell Biology

Background:

  • Growth hormone (GH) and insulin-like growth factors (IGFs) influence reproductive development during puberty.
  • Evidence suggests GH has a physiological role in adult ovarian function, potentially acting as a co-gonadotrophin.
  • The intra-ovarian IGF system is implicated in follicular atresia and disorders like polycystic ovary syndrome (PCOS).

Purpose of the Study:

  • To investigate the physiological role of growth hormone (GH) in adult ovarian function.
  • To explore the impact of GH and IGFs on granulosa cell proliferation and steroidogenesis.
  • To evaluate the clinical significance of GH in various ovulatory disorders and assisted reproductive technologies.

Main Methods:

  • Review of existing literature on GH, IGFs, and ovarian function.

Related Experiment Videos

  • Analysis of studies on granulosa cell proliferation and steroidogenesis in response to GH and IGFs.
  • Examination of clinical trial data regarding GH supplementation in women with hypogonadotrophic hypogonadism, PCOS, and in IVF protocols.

    • Main Results:

    • GH and IGFs augment granulosa cell proliferation and steroidogenesis in human Graafian follicles.
    • Adjuvant GH treatment reduces exogenous gonadotrophin requirements for folliculogenesis in women with hypogonadotrophic hypogonadism.
    • GH supplementation shows no significant clinical benefit in managing PCOS or in superovulation for IVF.

    Conclusions:

    • Growth hormone acts as a co-gonadotrophin, influencing ovarian function in adults.
    • GH therapy is clinically beneficial for inducing folliculogenesis in specific cases of hypogonadotrophic hypogonadism.
    • GH supplementation is not recommended for PCOS management or standard IVF protocols due to lack of proven efficacy.