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Updated: Sep 23, 2026

Real-time Live Imaging of T-cell Signaling Complex Formation
Published on: June 23, 2013
Signal transduction in T lymphocytes
1Department of Internal Medicine, University of Iowa, Iowa City 52242, USA.
Abstract:
T lymphocytes utilize a variety of surface receptors to transmit environmental signals across the plasma membrane and initiate biochemical events leading to responses such as proliferation, anergy, cytokine secretion, and death. The T cell receptor complex, CD28, IL-2 receptor, and CD95 each couple to distinct sets of cytoplasmic signaling events to modulate the biological responses of T cells. Deficiency or defective function of proteins involved in signaling through these receptors are associated with murine and human disease.
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