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Advances in antiviral therapy.

D M Zerr1, L M Frenkel

  • 1Department of Pediatrics, University of Washington, Children's Hospital and Regional Medical Center, Seattle 98105, USA.

Current Opinion in Pediatrics
|March 20, 1999
PubMed
Summary

New antiviral drugs offer promising treatments for common and rare pediatric viral infections. While some agents require further pediatric study, advances in antiviral therapy are improving care for children.

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Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Pharmacology

Background:

  • Recent years have seen the development of multiple antiviral agents, partly driven by the HIV-1 epidemic.
  • Several new antiviral medications are pertinent to general pediatric practice.
  • Advances in antiviral therapy are crucial for managing pediatric viral infections.

Purpose of the Study:

  • To review recent advancements in the therapy of viral illnesses in children.
  • To discuss the indications and efficacy of newly developed antiviral agents.
  • To highlight new applications of existing antiviral drugs.

Main Methods:

  • Review of newly developed antiviral agents including valacyclovir, famciclovir, cidofovir, ganciclovir, adefovir, RSV immune globulin, palivizumab, and imiquimod.
  • Discussion of new uses for acyclovir, lamivudine, and ribavirin.
  • Analysis of potential applications in pediatric viral infections.

Main Results:

  • Valacyclovir, famciclovir, cidofovir, oral and intraocular ganciclovir, adefovir, respiratory syncytial virus immune globulin, palivizumab, and imiquimod are discussed for their indications and efficacy.
  • New uses for acyclovir, lamivudine, and ribavirin are presented.
  • Several agents, including valacyclovir and cidofovir, show promise despite limited pediatric study.

Conclusions:

  • Newly developed antiviral agents hold significant promise for improving the treatment of pediatric viral infections.
  • Further research and clinical studies in children are needed for some promising antivirals.
  • Advances in antiviral therapy are expanding options for managing viral illnesses in pediatric patients.

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