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Rho Chi lecture. Pharmaceutical sciences in the next millennium.

D J Triggle1

  • 1The Graduate School, State University of New York, Buffalo 14260, USA. triggle@buffalo.edu

The Annals of Pharmacotherapy
|March 20, 1999
PubMed
Summary

The pharmaceutical sciences are rapidly evolving due to new technologies and economic pressures. Future drug discovery may involve molecular machines and new research models integrating science and technology.

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Area of Science:

  • * Pharmaceutical Sciences
  • * Drug Discovery and Development
  • * Biotechnology

Background:

  • * Rapid transformation of pharmaceutical sciences driven by technological advancements and economic imperatives.
  • * Emerging scientific paradigms in lead discovery, including directed diversity, self-reproduction, evolution, and self-targeting, inspired by molecular biology.
  • * Integration of nanotechnology for advanced drug delivery systems, such as targeted molecular machines.

Discussion:

  • * Economic pressures necessitate cost reduction in drug discovery, emphasizing efficiency and integration of development into the discovery phase.
  • * Formation of strategic alliances and entrepreneurial research cells within or outside pharmaceutical companies to streamline discovery processes.
  • * Shift from linear science-to-technology models towards integrated approaches linking scientific research, development, and technology.

Key Insights:

  • * Molecular biology and nanotechnology offer new paradigms for accelerated and targeted drug discovery.
  • * Economic factors are driving organizational changes, including increased collaborations and specialized research units.
  • * The traditional linear model of scientific advancement is being replaced by more interconnected research and development frameworks.

Outlook:

  • * Increased collaboration between the pharmaceutical industry and universities, fostering innovation and transforming universities into 'knowledge factories'.
  • * Expect significant changes in research organizational structures within the pharmaceutical sciences.
  • * Anticipation of future challenges and continued transformation despite current industry prosperity.

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