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Increase in plasma interleukin-10 following hydrocortisone injection
1Division of Endocrinology, State University of New York at Buffalo and KALEIDA Health, New York 14209, USA.
The Journal of Clinical Endocrinology and Metabolism
|March 20, 1999
Summary
Hydrocortisone administration significantly increases plasma interleukin-10 (IL-10) levels in healthy individuals. This finding may explain glucocorticoid immunosuppression and aid in assessing Cushing's Syndrome.
Area of Science:
- Immunology
- Endocrinology
Background:
- Glucocorticoids possess immunosuppressive properties.
- Interleukin-10 (IL-10) inhibits T helper cell function.
Purpose of the Study:
- To investigate the effect of hydrocortisone on plasma IL-10 concentrations.
Main Methods:
- Seven healthy subjects received an intravenous injection of 100 mg hydrocortisone.
- Blood samples were collected at multiple time points (pre-injection, 1, 2, 4, 8, and 24 hours post-injection).
Main Results:
- Plasma IL-10 concentrations showed a significant and consistent increase following hydrocortisone injection.
- Peak IL-10 levels were observed at 4 hours post-injection, with a 436% increase from baseline.
- IL-10 levels returned to baseline by 8 hours post-injection.
Conclusions:
- Hydrocortisone administration elevates plasma IL-10 levels.
- This effect may contribute to the immunosuppressive actions of glucocorticoids.
- Elevated IL-10 could serve as a marker for glucocorticoid end-organ effects in Cushing's Syndrome.