[Experimental affecting of pulmonary clearance of Pasteurella multocida induced pneumonia in swine]

The pulmonary clearance of Pasteurella multocida in weaner pigs was not affected by Carrageenan and Silica, two substances which block the function of monocytes/macrophages. Neutropenia, caused by the application of hydroxyurea, however, inhibit the pulmonary clearance markedly and reduced the severity of simultaneously induced pneumonias considerably. This indicates the importance of polymorphonuclear neutrophils for early clearance mechanisms and their inflammation inducing and maintaining effects.