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Updated: Jul 10, 2026

Pseudomonas aeruginosa Induced Lung Injury Model
Published on: October 29, 2014
Biological effects of Pseudomonas aeruginosa type III-secreted proteins on CHO cells
A J Vallis1, V Finck-Barbançon, T L Yahr
1Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Abstract:
A strain of Pseudomonas aeruginosa that fails to express known type III-secreted effector proteins was constructed as an expression host. Individual effectors were expressed in trans, and their biological effects on CHO cells were assessed in an acute cellular infection model. Intoxication with ExoS, ExoT, or ExoY resulted in alterations in cell morphology. As shown in previous genetic studies, ExoU expression was linked to acute cytotoxicity.
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