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Factor V Leiden mutation: a nursing perspective.

M J Page1

  • 1Hemophilia and Thrombosis Center, Fairview-University Medical Center, Minneapolis, Minnesota 55455, USA.

Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing
|March 23, 1999
PubMed
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The factor V Leiden mutation significantly increases the risk of venous thromboembolism (VTE). Women using oral contraceptives or who are pregnant face even higher VTE risks with this genetic disorder.

Area of Science:

  • Genetics
  • Hematology

Background:

  • Factor V Leiden mutation is an autosomal dominant genetic risk factor for venous thromboembolism (VTE).
  • Heterozygous carriers face a 4-7 times increased VTE risk, while homozygous carriers have a 50-100 times increased risk.

Observation:

  • Women with the factor V Leiden mutation experience a substantially elevated VTE risk when combined with pregnancy or oral contraceptive use.
  • The article reviews the mutation's inheritance, ethnic distribution, and its specific impact on women's health.

Findings:

  • Factor V Leiden mutation is a key genetic determinant of VTE.
  • Combined risks with hormonal factors (oral contraceptives, HRT) and pregnancy are significantly amplified.

Implications:

  • Genetic screening for factor V Leiden is crucial for risk assessment and management.

Related Experiment Videos

  • Nurses require specialized knowledge for counseling, risk reduction, and long-term care, addressing quality of life for affected individuals.