Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormonal changes in thalassaemia major.

D M Flynn, A Fairney, D Jackson

    Archives of Disease in Childhood
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Early dietary management of sugar intolerance in infancy.

    British medical journal·2010
    Same author

    Stability of serum total N-terminal propeptide of type I collagen.

    Annals of clinical biochemistry·2009
    Same author

    Vitamin D deficiency masking primary hyperparathyroidism.

    Annals of clinical biochemistry·2004
    Same author

    Bone loss associated with the use of LHRH agonists in prostate cancer.

    Prostate cancer and prostatic diseases·2002
    Same author

    Vertebral deformities and low bone mineral density in adults with cystic fibrosis: a cross-sectional study.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2001
    Same author

    Response to alendronate in osteoporosis after previous treatment with etidronate.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2000
    Same journal

    Diagnostic accuracy study assessing the ability of paediatric asthma scores to predict admission following initial emergency department bronchodilator therapy: a Clinical Asthma Scoring systems in Paediatric Emergency (CASPER) study.

    Archives of disease in childhood·2026
    Same journal

    Artificial intelligence for child health: current capabilities and the next frontier.

    Archives of disease in childhood·2026
    Same journal

    Troubled origins and lasting impact of the first insulin injection.

    Archives of disease in childhood·2026
    Same journal

    Paediatric readiness assessment tools in emergency care: a scoping review.

    Archives of disease in childhood·2026
    Same journal

    Building a paediatric workforce to deliver the NHS prevention agenda: time for paediatric public health medicine?

    Archives of disease in childhood·2026
    Same journal

    Impact of antenatal biological response modifying drugs on infant infection risk and vaccination rates: a national cohort study.

    Archives of disease in childhood·2026
    See all related articles

    Severe thalassemia major patients experience endocrine dysfunction, including thyroid, parathyroid, and hormonal imbalances, linked to iron overload from transfusions. These abnormalities impact growth and glucose metabolism, highlighting the need for careful monitoring.

    Area of Science:

    • Endocrinology
    • Hematology
    • Pediatrics

    Background:

    • Severe thalassemia major necessitates frequent blood transfusions, leading to iron overload.
    • Iron overload can cause significant endocrine and other organ abnormalities.
    • Previous studies often lacked accurate iron loading data and parathyroid assessment.

    Purpose of the Study:

    • To investigate the endocrine status of patients with severe thalassemia major.
    • To correlate endocrine abnormalities with the degree of iron loading.
    • To assess thyroid, parathyroid, glucose metabolism, and pubertal hormone levels.

    Main Methods:

    • Evaluated 31 patients (aged 2.5-23 years) with severe thalassemia major.
    • Assessed endocrine function including thyroid hormones, glucose tolerance, insulin levels, parathyroid hormone, and gonadotropins (LH, FSH).

    Related Experiment Videos

  • Correlated endocrine findings with transfusion history and liver iron concentration.

    • Main Results:

    • Patients exhibited lower thyroxine and higher thyrotropin levels, impaired glucose tolerance with diabetes in 5/19, and hypoparathyroidism in 2/31.
    • Parathyroid hormone levels were below average in all 25 tested patients.
    • Delayed puberty and varied LH/FSH levels were observed, with severity linked to iron loading.

    Conclusions:

    • Severe thalassemia major is associated with widespread endocrine dysfunction, including thyroid, parathyroid, and gonadal abnormalities.
    • Iron overload is a key factor contributing to these endocrine changes.
    • Accurate assessment of iron loading and endocrine status is crucial for managing patients with thalassemia major.