Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does endoscopic sphincterotomy cause prolonged pancreatobiliary reflux?

M Sugiyama1, Y Atomi

  • 1First Department of Surgery, Kyorin University School of Medicine, Tokyo, Japan.

The American Journal of Gastroenterology
|March 23, 1999
PubMed
Summary

Endoscopic sphincterotomy (ES) causes temporary pancreaticobiliary reflux, but it resolves within one year. This procedure is unlikely to increase biliary cancer risk if complications like cholangitis do not recur.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosis of anomalous pancreaticobiliary junction: value of magnetic resonance cholangiopancreatography.

Surgery·1998
Same author

Purification and characterization of a puromycin-hydrolyzing enzyme from blasticidin S-producing Streptomyces morookaensis.

Journal of biochemistry·1998
Same author

Expression of activin A is increased in cirrhotic and fibrotic rat livers.

Gastroenterology·1998
Same author

Effect of extremely low dose cyclosporine treatment on the thrombocytopenia in systemic lupus erythematosus.

Lupus·1998
Same author

Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 photoproducts in Arabidopsis thaliana.

Nucleic acids research·1998
Same author

Intraductal papillary tumors of the pancreas: evaluation with magnetic resonance cholangiopancreatography.

The American journal of gastroenterology·1998

Area of Science:

  • Gastroenterology
  • Hepatobiliary Surgery
  • Endoscopic Procedures

Background:

  • Endoscopic sphincterotomy (ES) impairs sphincter function, potentially leading to pancreatic juice and intestinal content reflux into the common bile duct.
  • Such reflux, along with anomalous pancreaticobiliary junction, may contribute to biliary tract carcinoma development.

Purpose of the Study:

  • To prospectively investigate the occurrence and duration of pancreatobiliary and duodenobiliary reflux following ES.
  • To assess the impact of ES on bile amylase concentration and bacterial presence.

Main Methods:

  • Ductal bile was sampled for amylase concentration and bacterial culture in 15 patients undergoing ES for choledocholithiasis.
  • Samples were collected before and at various times up to 5 years post-ES.

Related Experiment Videos

  • Comparative data were obtained from 11 patients without ES, including those with gallbladder polyps or anomalous pancreaticobiliary junction.

    • Main Results:

    • Amylase concentration in bile increased 7 days post-ES, reaching levels seen in patients with anomalous pancreaticobiliary junction, then gradually decreased, returning to baseline by 1 year.
    • Bactobilia (bacteria in bile) occurred in 60-80% of patients after ES, but no cases of acute cholangitis were observed.
    • Pre-ES bile amylase levels in choledocholithiasis patients were similar to those with gallbladder polyps.

    Conclusions:

    • ES induces transient pancreatobiliary reflux, which is fully resolved within one year.
    • ES is unlikely to elevate the risk of biliary tract carcinoma provided that cholangitis or bile duct stones do not recur.