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Related Experiment Videos

Lobar decrease in 99mTc-GSA accumulation in hilar cholangiocarcinoma.

S Akaki1, A Mitsumori, S Kanazawa

  • 1Department of Radiology, Okayama University Medical School, Japan.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|March 23, 1999
PubMed
Summary
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Hilar cholangiocarcinoma impacts liver function. Technetium-99m-GSA scintigraphy can predict reduced portal venous flow and monitor liver function lateralities in affected patients.

Area of Science:

  • Hepatobiliary imaging
  • Nuclear medicine
  • Surgical oncology

Background:

  • Hilar cholangiocarcinoma can obstruct bile ducts and portal veins.
  • Biliary stasis and reduced portal venous flow impair technetium-99m-diethylenetriamine pentaacetic acid-galactosyl human serum albumin (99mTc-GSA) accumulation.
  • The relationship between these factors and 99mTc-GSA uptake in hilar cholangiocarcinoma is unclear.

Purpose of the Study:

  • To clarify the relationship between hilar cholangiocarcinoma, biliary stasis, portal venous flow, and 99mTc-GSA accumulation.
  • To evaluate the utility of 99mTc-GSA scintigraphy in assessing liver function in these patients.

Main Methods:

  • Retrospective review of 16 patients with hilar cholangiocarcinomas who underwent 99mTc-GSA liver scintigraphy.

Related Experiment Videos

  • Evaluation of lobar biliary stasis and portal venous flow.
  • Comparison of 99mTc-GSA accumulation in right and left liver lobes using region of interest analysis and count ratios.

    • Main Results:

    • Six of 16 patients showed significant lobar decrease in 99mTc-GSA accumulation.
    • All 6 patients with decreased uptake had ipsilateral portal venous stenosis/obstruction, compared to 1 of 10 patients without uptake decrease.
    • Lobar 99mTc-GSA decrease correlated strongly with reduced ipsilateral portal venous flow (P < 0.0005).

    Conclusions:

    • 99mTc-GSA liver scintigraphy can predict lobar decrease in ipsilateral portal venous flow.
    • This imaging modality is useful for monitoring hepatic functional lateralities in patients with hilar cholangiocarcinomas.