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Transferrin receptor on peripheral blood lymphocytes in iron deficiency anaemia

S T Kinik1, A M Tuncer, C Altay

  • 1Department of Paediatrics, Hacettepe University, Ihsan Doğramaci Children's Hospital, Ankara, Turkey.

British Journal of Haematology
|March 23, 1999
PubMed

Insights

Iron deficiency anaemia (IDA) significantly reduces CD71 expression on lymphocytes in children. Oral iron therapy effectively restores CD71+ lymphocyte levels, indicating its role in immune function.

Area of Science:

  • Hematology
  • Immunology
  • Pediatrics

Background:

  • Iron deficiency anaemia (IDA) is a common condition in children.
  • CD71 (transferrin receptor) is expressed on proliferating cells, including lymphocytes.
  • The impact of IDA on lymphocyte CD71 expression requires further elucidation.

Purpose of the Study:

  • To investigate the effect of IDA on CD71 expression in pediatric peripheral blood lymphocytes.
  • To assess the correlation between CD71+ lymphocytes and hemoglobin levels in IDA patients.
  • To evaluate the changes in CD71+ lymphocyte counts following iron therapy.

Main Methods:

  • Flow cytometric analysis was used to enumerate CD71+ lymphocytes in peripheral blood.
  • Study included 43 children with IDA, 18 healthy controls, and 11 with beta-thalassaemia trait.
  • Nineteen IDA patients were monitored before and after 30 days of oral iron therapy.

Main Results:

  • Children with IDA showed significantly lower CD71+ lymphocyte percentages (5.90%) compared to healthy controls (12.60%).
  • A strong negative correlation was observed between CD71+ lymphocyte levels and hemoglobin in IDA patients.
  • Iron therapy increased CD71+ lymphocyte counts in IDA patients from 5.90% to 12.11%.

Conclusions:

  • Reduced CD71 expression on lymphocytes is a marker of IDA in children.
  • Lymphocyte CD71 expression is responsive to iron repletion.
  • Severe IDA may be associated with suppressed lymphocyte proliferation, impacting immune function.

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