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Related Experiment Videos

Elemental analysis mirrors epidermal differentiation.

B Forslind1, Y Werner-Linde, M Lindberg

  • 1Experimental Dermatology Research Group, Medical Biophysics, MBB, Karolinska Institute, Stockholm, Sweden. bosse@mango.mef.ki.se

Acta Dermato-Venereologica
|March 23, 1999
PubMed
Summary
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Elemental analysis reveals distinct differences in skin composition between healthy, psoriatic, and atopic dermatitis (AD) conditions. Psoriatic and AD skin show higher calcium gradients and abnormal iron and zinc levels, suggesting altered cell turnover and differentiation.

Area of Science:

  • Dermatology
  • Biophysics
  • Trace Element Analysis

Background:

  • Skin conditions like psoriasis and atopic dermatitis (AD) exhibit altered cellular processes.
  • Understanding elemental distribution in skin may provide insights into disease mechanisms.

Purpose of the Study:

  • To map the distribution of elements and trace elements in normal, non-lesional psoriatic, and dry atopic skin cross sections.
  • To investigate potential correlations between elemental profiles and skin pathologies.

Main Methods:

  • Utilized a scanning nuclear microprobe for elemental mapping.
  • Analyzed skin cross sections from normal, non-lesional psoriatic, and dry atopic skin.

Main Results:

  • Non-lesional psoriatic and dry atopic skin displayed a higher epidermal calcium (Ca) gradient compared to normal skin.

Related Experiment Videos

  • Abnormally high iron (Fe) and zinc (Zn) levels were observed in the stratum granulosum and corneum of pathological skin.
  • The Ca/Zn ratio in the stratum corneum differed significantly: 8:1 in psoriatic skin, 12:1 in normal skin, and 15:1 in atopic skin.

    • Conclusions:

    • Elevated Ca gradients and abnormal Fe/Zn levels in psoriatic and AD skin may indicate increased cell turnover in the basal layer.
    • The altered Ca/Zn ratio in psoriatic skin suggests a disturbance in programmed cell death during the differentiation process.