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Related Experiment Videos

Fibromyalgia in lupus erythematosus.

A Gräfe1, U Wollina, B Tebbe

  • 1Department of Dermatology, Friedrich-Schiller-University Jena, Germany.

Acta Dermato-Venereologica
|March 23, 1999
PubMed
Summary

Fibromyalgia is common in systemic lupus erythematosus, affecting 10 of 60 patients. This study found fibromyalgia is distinct from lupus activity and may increase the risk of misinterpreting lupus symptoms.

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Area of Science:

  • Rheumatology
  • Immunology
  • Pain Medicine

Background:

  • Fibromyalgia is frequently observed in systemic lupus erythematosus.
  • Limited data exist on fibromyalgia prevalence in other lupus subsets and its risk factors.

Purpose of the Study:

  • To investigate the prevalence of fibromyalgia in patients with various lupus erythematosus subsets.
  • To identify associations between fibromyalgia and clinical/laboratory parameters, and disease activity.
  • To compare fibromyalgia occurrence across different lupus subsets.

Main Methods:

  • Sixty patients with lupus erythematosus subsets were assessed for fibromyalgia based on tender points and pain duration.
  • Clinical and laboratory data were collected and compared with a lupus registry.

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  • A subset of 30 patients underwent a 1-year follow-up to evaluate fibromyalgia symptoms and lupus disease activity.

    • Main Results:

    • Ten out of 60 lupus patients (16.7%) met fibromyalgia criteria, all female.
    • Fibromyalgia-positive patients reported more headache, morning stiffness, alopecia, muscle pain, arthralgia, renal involvement, cytopenia, rheumatoid factor, hypergammaglobulinaemia, and corticosteroid/azathioprine use.
    • Fibromyalgia was more prevalent in systemic lupus than other subsets, but did not correlate with lupus activity during follow-up.

    Conclusions:

    • Fibromyalgia and lupus erythematosus appear to be distinct conditions.
    • Patients with lupus erythematosus are at increased risk for developing secondary fibromyalgia.
    • Fibromyalgia symptoms in lupus patients may complicate the assessment of lupus disease activity.