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Multiple A waves in Guillain-Barré syndrome
M E Kornhuber1, C Bischoff, H Mentrup
1Technische Universität, München, Germany.
Muscle & Nerve
|March 23, 1999
Summary
Multiple A waves are a sensitive early sign of Guillain-Barré syndrome (GBS), detected in most patients via electroneurography. These findings suggest A waves, like conduction block, indicate nerve inflammation in GBS.
Area of Science:
- Neurology
- Neurophysiology
Background:
- Guillain-Barré syndrome (GBS) is an autoimmune disorder affecting peripheral nerves.
- Electroneurography is crucial for diagnosing GBS and assessing nerve function.
Purpose of the Study:
- To investigate the presence and significance of A waves in the early diagnosis of GBS.
- To determine if A waves correlate with other electrophysiological findings in GBS.
Main Methods:
- Routine electroneurographic studies were performed on 14 GBS patients within 7 days of symptom onset.
- Analysis focused on the presence, number, and amplitude of A waves in limb nerves.
- Correlation analysis was conducted between A waves and compound muscle action potential (CMAP) amplitude reduction.
Main Results:
- Multiple A waves were observed in 13 of 14 GBS patients.
- A significant correlation was found between the number of A waves and reduced CMAP amplitude.
- Most A waves were low amplitude and not constantly elicitable.
Conclusions:
- The presence of multiple A waves is a sensitive early indicator of GBS.
- A waves, along with conduction block, are likely indicators of inflammatory nerve lesions in GBS.