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Related Experiment Videos

Fluoride supplements and fluorosis: a meta-analysis.

A I Ismail1, R R Bandekar

  • 1Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor 48109-1078, USA. ismailai@umich.edu

Community Dentistry and Oral Epidemiology
|March 23, 1999
PubMed
Summary

Regular use of fluoride supplements in non-fluoridated areas during tooth development significantly increases the risk of dental fluorosis. This review found a strong association between supplement use and fluorosis development in children.

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Area of Science:

  • Dental Public Health
  • Pediatric Dentistry
  • Preventive Dentistry

Background:

  • Dental fluorosis is a condition affecting tooth enamel.
  • Fluoride supplements are often recommended for caries prevention in non-fluoridated communities.
  • The relationship between fluoride supplement use and dental fluorosis risk requires thorough investigation.

Purpose of the Study:

  • To systematically review the literature on the association between fluoride supplement use and dental fluorosis.
  • To quantify the risk of developing dental fluorosis in children using fluoride supplements.
  • To assess the impact of fluoride supplements on dental health in non-fluoridated populations.

Main Methods:

  • Systematic review of English-language studies published between 1966 and 1997.

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  • MEDLINE search using keywords: fluorosis, dental, fluoride, fluoride supplement, drop, tablet.
  • Inclusion of 24 studies assessing dental fluorosis development in children with prior fluoride supplement use.
  • Quantitative meta-analysis of cross-sectional/case-control and follow-up studies.

    • Main Results:

    • A consistent and strong association was found between fluoride supplement use and dental fluorosis.
    • Meta-analysis of cross-sectional/case-control studies showed an odds ratio for dental fluorosis between 2.4 and 2.6.
    • Meta-analysis of follow-up studies indicated a relative risk for long-term users ranging from 5.5 to 12.2.
    • Significant increase in dental fluorosis risk observed in users of fluoride supplements.

    Conclusions:

    • The use of fluoride supplements during the first six years of life in non-fluoridated communities is linked to a significant increase in dental fluorosis risk.
    • Findings confirm the association between fluoride supplement intake and the development of dental fluorosis.
    • This review highlights the importance of careful consideration regarding fluoride supplement prescription in areas without optimal water fluoridation.