Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The human immunoglobulin heavy variable genes.

N Pallarès1, S Lefebvre, V Contet

  • 1Laboratoire d'ImmunoGénétique Moléculaire, CNRS, Université Montpellier II, Montpellier, France.

Experimental and Clinical Immunogenetics
|March 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multicenter COVID-19 database from four waves in the south metropolitan area of Barcelona, Catalonia.

Scientific data·2026
Same author

Development and validation of a model to predict ceiling of care in COVID-19 hospitalized patients.

BMC palliative care·2024
Same author

[Assessment of lower urinary tract symptoms as part of falls screening : Knowledge and practice of health care workers involved in the management of older people].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2022
Same author

Mycotoxins in raw materials, beverages and supplements of botanicals: A review of occurrence, risk assessment and analytical methodologies.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2022
Same author

Inferring functional traits in a deep-sea wood-boring bivalve using dynamic energy budget theory.

Scientific reports·2021
Same author

Analysis of outcomes of emergency general and gastrointestinal surgery during the COVID-19 pandemic.

The British journal of surgery·2021
Same journal

Nomenclature and overview of the mouse (Mus musculus and Mus sp.) immunoglobulin kappa (IGK) genes.

Experimental and clinical immunogenetics·2002
Same journal

Nomenclature of the human immunoglobulin lambda (IGL) genes.

Experimental and clinical immunogenetics·2002
Same journal

Oligonucleotide fishing for STAT6: cross-talk between IL-4 and chemokines.

Experimental and clinical immunogenetics·2002
Same journal

Use of human recombinant DNase I expressed in COS-7 cells as an immunogen to produce a specific anti-DNase I antibody.

Experimental and clinical immunogenetics·2002
Same journal

In situ activated intestinal T cells expanded in vitro--without addition of antigen--produce IFN-gamma and IL-10 and preserve their function during growth.

Experimental and clinical immunogenetics·2002
Same journal

Increased frequency of the C3*F allele and the Leiden mutation of coagulation factor V in patients with severe coronary heart disease who survived myocardial infarction.

Experimental and clinical immunogenetics·2002
See all related articles

This report details human immunoglobulin heavy variable (IGHV) genes, including germline and orphon genes on specific chromosomes. The findings are presented in five comprehensive tables available via the IMGT database.

Area of Science:

  • Immunogenetics
  • Genomics
  • Molecular Biology

Background:

  • The IMGT Locus on Focus series provides critical data on immunoglobulin and T cell receptor genes.
  • Accurate characterization of the human immunoglobulin heavy variable (IGHV) gene repertoire is essential for understanding immune responses.

Purpose of the Study:

  • To present a comprehensive catalog of human germline IGHV genes and orphon sequences.
  • To update and consolidate information on human IGHV gene organization and allelic variations.

Main Methods:

  • Compilation and curation of data from existing literature and databases.
  • Organization of information into five distinct, detailed tables.
  • Provision of access to the data through the IMGT (the international ImMunoGeneTics database) website.

Related Experiment Videos

Main Results:

  • Detailed enumeration of human germline IGHV genes located at 14q32.33 and their potential repertoire.
  • Identification and characterization of human IGHV orphons on chromosomes 15 (15q11.2) and 16 (16p11.2).
  • A comprehensive human IGHV allele table summarizing known variations.

Conclusions:

  • The presented tables offer a valuable resource for researchers in immunogenetics and related fields.
  • This work enhances the understanding of the complexity and organization of the human IGHV locus.
  • Accessibility through IMGT facilitates further research and analysis of the human immune system's genetic basis.