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[Changes in ionized magnesium concentrations during general anesthesia].

T Okuda1, M Kura, K Hatsuoka

  • 1Department of Anesthesiology, Kinki University School of Medicine, Osakasayama.

Masui. the Japanese Journal of Anesthesiology
|March 24, 1999
PubMed
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Anesthesia significantly reduces ionized magnesium levels during surgery. Thiamylal induction led to lower ionized magnesium compared to ketamine, while total magnesium remained stable.

Area of Science:

  • Anesthesiology
  • Biochemistry
  • Critical Care Medicine

Background:

  • Ionized magnesium (Mg) plays a crucial role in physiological processes.
  • Understanding Mg fluctuations during anesthesia is vital for patient safety.
  • Isoflurane-nitrous oxide-oxygen anesthesia is commonly used in surgical settings.

Purpose of the Study:

  • To investigate the changes in ionized magnesium concentration during isoflurane-nitrous oxide-oxygen anesthesia.
  • To compare the effect of two different anesthetic induction methods (thiamylal vs. ketamine) on ionized magnesium levels.
  • To assess the impact of anesthesia on serum total magnesium, ionized calcium, sodium, and potassium concentrations.

Main Methods:

  • Patients were divided into two groups based on anesthetic induction: thiamylal (Group 1) or ketamine (Group 2).

Related Experiment Videos

  • Ionized magnesium concentration was measured using a NOVA 8 analyzer during anesthesia.
  • Serum total magnesium, ionized calcium, sodium, and potassium levels were also recorded.

    • Main Results:

    • Ionized magnesium concentration significantly decreased in both groups during anesthesia induction and surgery.
    • The decrease in ionized magnesium was more pronounced after thiamylal induction compared to ketamine induction.
    • Serum total magnesium concentration remained unchanged throughout the anesthesia course.
    • Ionized calcium levels decreased, while sodium and potassium concentrations showed no significant changes.

    Conclusions:

    • Ionized magnesium concentration decreases during general anesthesia and surgery.
    • Anesthetic agents may affect cell membranes, contributing to the observed decrease in ionized magnesium.
    • The induction agent influences the extent of ionized magnesium reduction during anesthesia.