Related Experiment Video
Updated: Aug 8, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
Published on: April 13, 2015
[Correlation between the count of the various intraepithelial mononuclear leukocytes and tumor progression in the
K I Panchenko1, A S Nadezhin, E V Evgen'eva
1State Medical Academy, Yaroslavl.
Abstract:
A study of 35 gastrobioptates sampled from benign epithelial proliferates, adenomas with advanced epithelial dysplasia and adenocarcinomas was conducted using standard original procedures of staining and DNA identification. Also, the method of direct immunoluminescence using fluoroesceinisothiocymate-labeled monoclonal antibodies against human antigens CD4, CD8, CD25 and CD45 was employed. It was found that, among microscopic intraepithelial mononuclear leukocytes, only few bear the immunohistochemical markers of activity. The distribution of intraepithelial mononuclear leukocytes in the stomach of a cancer patient is changed.
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