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Presumed moxidectin toxicosis in three foals.
P J Johnson1, D R Mrad, A J Schwartz
1Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
Journal of the American Veterinary Medical Association
|March 24, 1999
Summary
Moxidectin gel can cause severe adverse effects, including coma and death, in foals under four months old. Overdosing risk is high due to improper use of the administration syringe.
Area of Science:
- Veterinary pharmacology
- Equine medicine
Background:
- Moxidectin is an antiparasitic drug commonly used in horses.
- Accurate dosing is crucial for safe and effective treatment.
Observation:
- Three foals under four months old were administered moxidectin gel.
- Two foals experienced coma but recovered with supportive care.
- One foal died after losing consciousness post-administration.
Findings:
- Moxidectin administration in foals under four months old carries a significant risk of overdose.
- Improper use of the syringe-locking mechanism by owners contributes to overdose risk.
- Coma and mortality are potential outcomes of moxidectin administration in young foals.
Implications:
- Moxidectin should not be administered to foals younger than four months.
- Veterinarians and horse owners must be educated on correct moxidectin administration and risks.
- Further research into safe moxidectin dosing for neonatal foals is warranted.