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Neurologic abnormalities associated with persistent hyperplastic primary vitreous.

W E Marshman1, J E Jan, C J Lyons

  • 1Department of Ophthalmology, British Columbia's Children's Hospital, Vancouver, BC.

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|March 24, 1999
PubMed
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Persistent hyperplastic primary vitreous (PHPV) can be associated with significant neurological issues, especially in bilateral cases. Early consideration of neurological evaluation is crucial for affected children.

Area of Science:

  • Ophthalmology
  • Neurology
  • Pediatrics

Background:

  • Persistent hyperplastic primary vitreous (PHPV) is typically an isolated, unilateral ocular condition.
  • This study investigated a cohort of patients with PHPV, including those with bilateral involvement.
  • A notable proportion of patients presented with co-occurring systemic neurological abnormalities.

Purpose of the Study:

  • To identify and characterize neurological deficits in patients diagnosed with PHPV.
  • To determine the association between the laterality of PHPV (unilateral vs. bilateral) and the presence of neurological abnormalities.
  • To highlight the importance of considering neurological comorbidities in PHPV cases.

Main Methods:

  • Retrospective review of clinical records for 16 children with PHPV.

Related Experiment Videos

  • Inclusion criteria: patients referred to a university-affiliated children's hospital's Visually Impaired Program.
  • Neurological assessment included electroencephalography, computed tomography, and pediatric neurological evaluation.

    • Main Results:

    • Neurological abnormalities were found in 3 of 7 children with unilateral PHPV.
    • Significant neurological deficits were identified in 7 of 9 children with bilateral PHPV.
    • Observed neurological conditions included hemiparesis, ataxia, hypotonia, spastic quadriplegia, microcephaly, deafness, and coordination impairments.

    Conclusions:

    • PHPV, particularly bilateral cases, warrants consideration for underlying neurological abnormalities.
    • Referral to a pediatric neurologist is recommended for comprehensive evaluation.
    • Early detection of neurological comorbidities can improve patient management and outcomes.