Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Measuring response in solid tumors: unidimensional versus bidimensional measurement.

K James1, E Eisenhauer, M Christian

  • 1National Cancer Institute of Canada Clinical Trials Group, Queen's University, Kingston, ON. jamesk@ncic.ctg.queensu.ca

Journal of the National Cancer Institute
|March 24, 1999
PubMed
Summary

A new unidimensional measurement for tumor shrinkage is proposed as a simpler alternative to the standard bidimensional method. This approach may be sufficient for assessing solid tumor changes in clinical trials.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Women with chronic constipation have more bothersome urogenital symptoms.

Techniques in coloproctology·2021
Same author

Male factor infertility and placental pathology in singleton live births conceived with in vitro fertilization.

Journal of assisted reproduction and genetics·2021
Same author

Letter to the Editor: An Unknown Unknown: Early Identification of Dysphagia in Frail Patients in the Emergency Department.

The journal of nutrition, health & aging·2021
Same author

Should there be an "AI" in TEAM? Embryologists selection of high implantation potential embryos improves with the aid of an artificial intelligence algorithm.

Journal of assisted reproduction and genetics·2021
Same author

The incidence, aetiology, and coagulation management of massive postpartum haemorrhage: a two-year national prospective cohort study.

International journal of obstetric anesthesia·2021
Same author

Effect of surgical approach on risk of recurrence after vaginal brachytherapy in early-stage high-intermediate risk endometrial cancer.

Gynecologic oncology·2020

Area of Science:

  • Oncology
  • Clinical Trial Design
  • Biostatistics

Background:

  • Tumor shrinkage is a key endpoint in evaluating new cytotoxic agents.
  • The World Health Organization (WHO) uses a 50% decrease in the sum of bidimensional products for partial response.
  • A simpler unidimensional criterion based on maximum tumor diameter has been proposed.

Purpose of the Study:

  • To compare the standard WHO bidimensional criteria with a new unidimensional criterion for assessing tumor response.
  • To determine if the unidimensional criterion yields similar patient response rates as the bidimensional method.
  • To evaluate the utility of unidimensional measurements in assessing solid tumor changes.

Main Methods:

  • Reanalyzed data from 569 cancer patients across eight studies.

Related Experiment Videos

  • Applied both standard bidimensional and proposed unidimensional response criteria separately.
  • Compared results using the kappa statistic and examined confirmatory measurements and tumor shapes.
  • Assessed a unidimensional progression criterion against the standard bidimensional definition in 128 patients.

    • Main Results:

    • Good agreement was observed between the unidimensional and bidimensional criteria for overall response.
    • The kappa statistic for concordance was 0.95, indicating high agreement.
    • The unidimensional criterion for disease progression also showed good concordance with the standard definition.

    Conclusions:

    • One-dimensional measurement of maximum tumor diameter may be sufficient for assessing changes in solid tumors.
    • The proposed unidimensional criterion offers a potentially simpler and equally effective method for tumor response assessment.
    • This simplification could streamline the evaluation of cytotoxic agents in clinical settings.