Related Experiment Video

Updated: Aug 18, 2026

Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain
10:52

Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain

Published on: September 21, 2015

Congenital insensitivity to pain with anhidrosis: ocular and systemic manifestations

R Yagev1, J Levy, Z Shorer

  • 1Department of Ophthalmology, Soroka Medical Center and Ben-Gurion University, Beer-Sheva, Israel. yagevy@netvision.net.il

American Journal of Ophthalmology
|March 24, 1999
PubMed

Insights

Congenital insensitivity to pain with anhidrosis (CIPA) causes absent corneal sensation, leading to frequent, poorly healing corneal ulcers. CIPA should be considered in neurotrophic keratitis diagnosis.

Area of Science:

  • Ophthalmology
  • Neurology
  • Genetics

Background:

  • Congenital insensitivity to pain with anhidrosis (CIPA) is a rare genetic disorder.
  • Patients with CIPA lack pain sensation and the ability to sweat.
  • Ophthalmologic manifestations in CIPA are not well-documented.

Purpose of the Study:

  • To determine the incidence and severity of eye problems in children with CIPA.
  • To investigate the link between CIPA and corneal complications.

Main Methods:

  • Ocular and neurological examinations were performed on 15 children with CIPA.
  • Corneal sensation, refraction, and nerve conduction were assessed.
  • Corneal ulcers were treated, and surgical interventions were documented.

Main Results:

  • All 15 children had absent corneal sensation.
  • 10 children had corneal opacities, and 7 developed corneal ulcers, with recurrences in 3.
  • Patients experienced delayed healing of corneal and other injuries, hyperpyrexia, and mental retardation.

Conclusions:

  • Absent corneal sensation in CIPA patients leads to a high risk of severe corneal ulcers with poor healing.
  • CIPA is a crucial consideration in the differential diagnosis of neurotrophic keratitis.
  • Early recognition and management of ocular manifestations in CIPA are vital.
Abstract

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