Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is the Ras-MAPK signalling pathway necessary for long-term memory formation?

P C Orban1, P F Chapman, R Brambilla

  • 1San Raffaele Scientific Institute, Milano, Italy.

Trends in Neurosciences
|March 24, 1999
PubMed
Summary

The Ras signaling pathway, including mitogen-activated protein kinase (MAPK), is crucial for long-term memory and neuronal plasticity. Genetic disruption of Ras regulators impairs learning and memory in animal models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of harmful drinking in subjects who have had their driving license suspended due to alcohol use: a retrospective Italian study.

European review for medical and pharmacological sciences·2020
Same author

Flat Panel Angiography in the Cross-Sectional Imaging of the Temporal Bone: Assessment of Image Quality and Radiation Dose Compared with a 64-Section Multisection CT Scanner.

AJNR. American journal of neuroradiology·2017
Same author

18F-FDG PET/CT in the post-operative monitoring of patients with adrenocortical carcinoma.

European journal of endocrinology·2015
Same author

The value of precontrast thoraco-abdominopelvic CT in polytrauma patients.

European journal of radiology·2015
Same author

Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.

Cell death and differentiation·2015
Same author

Effects of the sol-gel route on the structural characteristics and antibacterial activity of silica-encapsulated gentamicin.

Colloids and surfaces. B, Biointerfaces·2014

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cellular Signaling

Background:

  • Protein kinase cascades are implicated in long-term potentiation (LTP) and memory.
  • Small GTPases like Ras regulate cellular events, including gene transcription, in response to stimuli.

Purpose of the Study:

  • To investigate the role of Ras-dependent signaling pathways in neuronal plasticity and memory formation.
  • To explore the involvement of the mitogen-activated protein kinase (MAPK) cascade in learning and memory.

Main Methods:

  • Genetic and pharmacological experiments in Aplysia and rodent models.
  • Analysis of LTP induction and memory deficits in genetically modified mice lacking Ras regulators.

Main Results:

Related Experiment Videos

  • Ras-dependent MAPK cascade activation is essential for long-term facilitation in Aplysia.
  • Inhibition of the MAPK pathway impairs LTP induction in rodents.
  • Mice lacking Ras-GRF exhibit deficits in amygdala LTP and aversive memory.

    • Conclusions:

    • Ras-dependent signaling pathways are critical for neuronal plasticity, including LTP.
    • These pathways play a significant role in learning and memory processes across different species.