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Related Experiment Videos

Transient left ventricular dysfunction in childhood sickle cell disease.

W H Johnson1, R B McCrary, V N Mankad

  • 1Department of Pediatrics, Division of Pediatric Cardiology, University of South Alabama College of Medicine, Mobile, AL, USA.

Pediatric Cardiology
|March 25, 1999
PubMed
Summary

Myocardial infarction is rare in childhood sickle cell disease, but cardiac dysfunction can occur. This case highlights reversible heart problems mimicking heart attacks in children with sickle cell disease.

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Area of Science:

  • Pediatric Cardiology
  • Hematology
  • Sickle Cell Disease Research

Background:

  • Sickle cell disease (SCD) commonly causes organ damage, including lung, bone, and brain infarcts.
  • Myocardial infarction (heart attack) is notably rare in pediatric SCD, despite risk factors like anemia and vasoocclusive crises.
  • Potential mechanisms for cardiac involvement include acute ischemia during crises and chronic volume overload due to anemia.

Observation:

  • A pediatric patient with sickle cell disease presented with symptoms suggestive of myocardial infarction.
  • Cardiac evaluation revealed significant myocardial dysfunction.
  • The patient's cardiac function improved over time, indicating a reversible condition.

Findings:

  • The case demonstrates reversible cardiac dysfunction in a child with sickle cell disease.

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  • This cardiac dysfunction mimicked the presentation of myocardial infarction.
  • The findings suggest that cardiac complications in pediatric SCD may manifest differently than previously understood.

    • Implications:

    • This case underscores the importance of considering myocardial dysfunction in children with SCD presenting with cardiac symptoms.
    • Early recognition and management of reversible cardiac dysfunction may improve outcomes in pediatric SCD.
    • Further research is needed to elucidate the mechanisms behind the rarity of myocardial infarction and the occurrence of reversible cardiac dysfunction in pediatric sickle cell disease.