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[Fatal toxoplasmosis in children].

M Salas Martínez

    Boletin Medico Del Hospital Infantil De Mexico
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Fatal prenatal toxoplasmosis in infants is severe due to increased parasite virulence in the fetus. Postmortem studies confirmed Toxoplasma gondii in the central nervous system, liver, and lungs.

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    Area of Science:

    • Medical Parasitology
    • Pediatric Pathology
    • Infectious Diseases

    Context:

    • Review of fatal toxoplasmosis cases at Hospital Infantil de México (1943-1973).
    • Inclusion of five postmortem studies identifying Toxoplasma in histologic lesions.
    • Analysis of clinical manifestations including infectious, intracranial hypertensive, neurological, and meningeal pictures.

    Purpose:

    • To review fatal toxoplasmosis cases and associated postmortem findings.
    • To investigate the identification of Toxoplasma gondii in infant tissues.
    • To correlate clinical presentation with neuropathological findings in congenital toxoplasmosis.

    Summary:

    • Toxoplasma gondii was identified within and outside parasitized cells, predominantly in the central nervous system, in all five postmortem cases.

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  • Severe fetal disease is hypothesized to result from increased parasite virulence in a second-step infection.
  • Lesion intensity correlated with clinical severity and early postnatal manifestations, with parasites found in the brain, liver, and lungs.

    • Impact:

    • Highlights the severe impact of congenital toxoplasmosis on fetal development.
    • Emphasizes the importance of postmortem examination in diagnosing parasitic infections.
    • Provides insights into the pathogenesis of severe fetal toxoplasmosis, suggesting enhanced virulence.